One of SANE’s key aims is to undertake research into the causes of mental illness and more effective treatments and therapies. The Prince of Wales International Centre for SANE Research (POWIC), based at Warneford Hospital, Oxford, hosts five teams of researchers. Professor Tim Crow continues his neuroscientific investigation into the origins of psychotic illness, while the Oxford Mindfulness Centre both trains and conducts research into this highly effective therapy, especially for people with recurring severe depression. In addition, the team under Professor Daniel Freeman is exploring why some people experience distressing paranoid feelings, especially under the influence of psychoactive drugs such as cannabis. Other research has focussed on new ways for patients to manage bipolar disorder and how the public and professionals can help to prevent suicide.